Minocycline hydrochloride capsules may be administered with or without food. The mean T max was delayed by one hour when administered with food, compared to dosing under fasting conditions. When minocycline hydrochloride capsules were given concomitantly with a high-fat meal, which included dairy products, the extent of absorption of minocycline hydrochloride capsules was unchanged compared to dosing under fasting conditions. The serum half-life in the normal volunteers ranged from 11.1 to 22.1 hours (average 15.5 hours). Following a single dose of two minocycline hydrochloride capsules, 100 mg administered to 18 normal fasting adult volunteers, maximum serum concentrations were attained in 1 to 4 hours (average 2.1 hours) and ranged from 2.1 to 5.1 µg/mL (average 3.5 µg/mL).
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